The mechanism of side effects of general anesthesia
The mechanism of side effects of general anesthesia
Research conducted by staff of the medical center at the University of Georgetown (USA), gives a scientific explanation for the paradoxical effect of general anesthesia, which eliminates the pain during the operation, but after the operation is finished and the anesthetic is removed, the feeling of pain remains.
The work of American doctors, published in the latest issue of the journal Proceedings of the National Academy of Sciences (PNAS), deals with important aspects of general anesthesia, which had previously been ignored scientists, despite the widespread medical use of this method of anesthesia.
Most of the currently used funds for general anesthetics cause irritation at the point of introduction into the body or in the upper airway during inhalation anesthesia. Although these funds depress the central nervous system, and they also activate the so-called nociceptive (pain) nerve cells in the peripheral nervous system, and anesthesiologists often first give patients drugs to suppress inflammation and pain, and only then to fund general anesthesia.
Until now, the mechanism by which drugs for general anesthesia in the neurons was unclear how long and cause pain and inflammation after surgery. In the nerve cells of humans, as well as some other animals, there are two specific receptor – TRPV1 and TRPA1, which react to some of the natural esters, in particular, of garlic or mustard oil.
Researchers from Georgetown suggest that these receptors can respond and the means for anesthesia. This hypothesis proved to be true – indeed, the receptor TRPA1, which is sometimes called the mustard oil receptor, is the most important element in the mechanism of pain reaction, it interacts directly with the substances used for general anesthesia, and is responsible for developing the body of pain and other unpleasant consequences of anesthesia .
The work of American doctors opens the prospect of creating new, more secure means of general anesthesia. They should be sought among those drugs that almost do not interact with the receptor TRPA1. Such drugs are, but they are less effective in its primary role, but you can find options to improve these indicators.
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