Generic medicines and equivalence
Generic medicines and equivalence
Fierce competition in the pharmaceutical market, explains that the issues of interchangeability of drugs have become the most slippery issues of conflict and the industry. Manufacturers of drugs unleashed a kind of information war, which reflect the two main fronts. The first is between drugs within the same group, and the second – between the original medicines and drugs, reproduced (generics). A striking example of these “military” actions can serve as a market situation statinovyh drugs. Indeed, the effectiveness of drugs after a triumphant holesterinsnizhayuschih research the past 10 years under almost certainly not intended. This market is currently co-exist several more or less equally effective drugs that help reduce the atherogenic cholesterol. In principle, the question of choosing between atorvastatin, pravastatin, or simvastaninom flyuvastatinom (drugs listed in alphabetical order) – is largely a question case. However, the direct and hidden advertising mislead consumers that atorvatatin – is “most powerful” drug, lovastatin “less toxic”, pravastatin “safer”, and simvastatin – “the most studied. Is it true? Probably only in part. However, fierce competition within the group led to the fact that cerivastatin, in regard to safety two years ago there was some doubt, departed from the market almost immediately, and the echoes of the stories heard and to this day. At the same time two other drug manufacturers in this group were explicitly warned by FDA about the inadmissibility of the use of the principle of transfer properties of drugs, typical for the group as a whole on the properties of a drug. Within this same group exemplifies the dissonance between the true and surrogate endpoint of the study: the advantage of speed and power reduction of atherogenic lipids has no direct correlation with the frequency of adverse outcomes.
Expiration of patent protection has led to that market, a considerable number of generic drugs statinovyh. And here the fighting went on another – more subtle and less understandable to practitioner level. Widely discussed issues began to be added to the tablet form of some components, which in the opinion of one company are just the same poisons. And according to another – added to the dosage form in an amount to one hundred times less than the maximum allowable. Explanations of the benefits of the original drug reproduced sometimes seem totally transcendental, but the argument of the company-developer of the original drug can understand and accept. Colossal funds that are spent searching for the manufacturer of the molecule drug substance, the study of medicine and its excretion in the market, careful monitoring of possible adverse effects and interactions of drugs – all of these funds over several years, during which continues to operate, patent protection, are irretrievably lost . Generic drugs, which are beginning to play a few companies at the same time, a priori “inherit” all the properties whose presence in the preparation of the original proved with huge costs. And then you can arbitrarily long argued that the original is always original, and the reproduction means – just reproduced means. The presence of general international nonproprietary names (INN) makes these drugs are absolutely similar in the eyes of the end user, that seems fair, given that often the original and generic drugs are made from the same substance.
Buy Aciphex Online – Order Aciphex
Buy Nexium Online – Order Nexium
Buy Prevacid Online – Order Prevacid
Buy Prilosec Online – Order Prilosec
Buy Zantac Online – Order Zantac
Buy Accutane Online – Order Accutane
Buy Levothroid Online – Order Levothroid
Buy Snoroff Online – Order Snoroff
Buy Topamax Online – Order Topamax
Buy Propecia Online – Order Propecia
Buy Finasteride Online – Order Finasteride
Buy Tamiflu Online – Order Tamiflu
Buy Valtrex Online – Order Valtrex
Buy Zovirax Online – Order Zovirax
Buy Effexor Online – Order Effexor
Buy Lexapro Online – Order Lexapro
Buy Paxil Online – Order Paxil
Buy Prozac Online – Order Prozac
Buy Wellbutrin Online – Order Wellbutrin
Buy Zoloft Online – Order Zoloft
Buy Amoxicillin Online – Order Amoxicillin
Buy Doxycycline Online – Order Doxycycline
Buy Zithromax Online – Order Zithromax
Buy Ibuprofen Online – Order Ibuprofen
Buy Advair Diskus Online – Order Advair Diskus
Buy Lisinopril Online – Order Lisinopril
Buy Vasotec Online – Order Vasotec
Buy Casodex Online – Order Casodex
Buy Nolvadex Online – Order Nolvadex
Buy Lipitor Online – Order Lipitor
Buy Zocor Online – Order Zocor
Leave your response!