Found genetic markers of psoriasis
Found genetic markers of psoriasis
Doctors of the University of Michigan, found “hot spots” of DNA that help determine the genetic differences in psoriasis, autoimmune skin disease.
Psoriasis causes painful sensations in the skin, redness, itching and the formation of scales. In many cases, the disease is not only disfigures the skin, but also promotes the development of arthritis and inflammation of the joints. Such complications affect 10 to 30 percent of patients. It psoriasis is often hereditary. A new 18-month study will lead to the development of new drugs, certain therapists. Some genes play an important role in the immune response in the development of psoriasis, in particular IL-23, TNFAIP3 and TNIP1, which doctors isolated as potential “fighters” against the diagnosis.
Scientists using innovative genomic technologies, scanning millions of variations of DNA in the genome of 1 thousand 359 patients and among the 1 thousand 400 healthy people to discover what specific genes responsible for psoriasis. In total, it was found seven of the 18 loci of points on the chromosome, have consistently strong associations with psoriasis. The result has been fleshed out four proteins of three genes, changes in people that predispose to chronic immune reactions. Dermatologists also learned that the genetic signals for protein TNF-alpha, the key signaling molecules are also involved in inflammation. The action of two genes, TNFAIP3 and TNIP1, showed a strong influence on the development of psoriasis. Create a directory of genetic data would accurately predict the likely incidence of psoriasis and to evaluate the risk of heart attack and stroke, because the skin disease often occur symptoms of coronary heart disease.
Leave your response!